Synthesis, Characterization and Biological Evaluation of 6-(5-Chloro-8-Hydroxynapthalene-2-yl)-4(4-Hydroxyphenyl)-4-5-Dihydroxypyrimidin-2(1h)-One

نویسندگان

چکیده

1-(4- Chloro -1-hydroxynaphthalen-2-yl)-ethanone was prepared by refluxing 4-chloronaphthalen-1-ol with glacial acetic acid in presence of fused ZnCl2. From this synthesized compound we -1- hydroxynaphthalen-2-yl)-3-(4-hydroxy phenyl)-prop-2-en-1-one from condensing -1-hydroxynaphthalen-2- yl)-ethenone, The final product 6-(5-chloro-8-hydroxynapthalene-2-yl)-4(4-hydroxyphenyl)-4-5-dihydroxypyrimidin-2(1h)-one, condensation urea and concentrated HCl DMF. compounds thus have been characterized physical spectral data. This titled screened for antimicrobial study are found to possess excellent activities due chlorine as a substituent on main nucleus.

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ژورنال

عنوان ژورنال: International Journal For Multidisciplinary Research

سال: 2022

ISSN: ['2582-2160']

DOI: https://doi.org/10.36948/ijfmr.2022.v04i06.1240